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Abstract Studies of model organisms have provided important insights into how natural genetic differences shape trait variation. These discoveries are driven by the growing availability of genomes and the expansive experimental toolkits afforded to researchers using these species. For example, Caenorhabditis elegans is increasingly being used to identify and measure the effects of natural genetic variants on traits using quantitative genetics. Since 2016, the C. elegans Natural Diversity Resource (CeNDR) has facilitated many of these studies by providing an archive of wild strains, genome-wide sequence and variant data for each strain, and a genome-wide association (GWA) mapping portal for the C. elegans community. Here, we present an updated platform, the Caenorhabditis Natural Diversity Resource (CaeNDR), that enables quantitative genetics and genomics studies across the three Caenorhabditis species: C. elegans, C. briggsae and C. tropicalis. The CaeNDR platform hosts several databases that are continually updated by the addition of new strains, whole-genome sequence data and annotated variants. Additionally, CaeNDR provides new interactive tools to explore natural variation and enable GWA mappings. All CaeNDR data and tools are accessible through a freely available web portal located at caendr.org.more » « less
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Ostilla-Mónico, Rodolfo; McKeown, Ryan; Brenner, Michael P.; Rubinstein, Shmuel M.; Pumir, Alain (, Physical Review Fluids)At high Reynolds number, the interaction between two vortex tubes leads to intense velocity gradients, which are at the heart of fluid turbulence. This vorticity amplification comes about through two different instability mechanisms of the initial vortex tubes, assumed anti-parallel and with a mirror plane of symmetry. At moderate Reynolds number, the tubes destabilize via a Crow instability, with the nonlinear development leading to strong flattening of the cores into thin sheets. These sheets then break down into filaments which can repeat the process. At higher Reynolds number, the instability proceeds via the elliptical instability, producing vortex tubes that are perpendicular to the original tube directions. In this work, we demonstrate that these same transition between Crow and Elliptical instability occurs at moderate Reynolds number when we vary the initial angle between two straight vortex tubes. We demonstrate that when the angle between the two tubes is close to =2, the interaction between tubes leads to the formation of thin vortex sheets. The subsequent breakdown of these sheets involves a twisting of the paired sheets, followed by the appearance of a localized cloud of small scale vortex structures. At smaller values of the angle between the two tubes, the breakdown mechanism changes to an elliptic cascade-like mechanism. Whereas the interaction of two vortices depends on the initial condition, the rapid formation of fine-scales vortex structures appears to be a robust feature, possibly universal at very high Reynolds numbers.more » « less
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McKeown, Ryan; Ostilla-Mónico, Rodolfo; Pumir, Alain; Brenner, Michael P.; Rubinstein, Shmuel M. (, Physical Review Fluids)
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